Analytics are an integral part of our Flowrence® high-throughput technology, and they play a crucial role in ensuring the quality of experimental data. At Avantium R&D Solutions, we believe that the analytic solutions used to acquire data should be optimized for different chemistries and platforms. Balancing the analysis of all components and optimizing cycle time are two critical considerations for each application. The importance of these factors varies depending on the specific case, with some applications prioritizing more data points while others require more detailed component information. 


The Flowrence® Technology leverages the advantage of keeping reactor products in the gas phase, allowing for the direct feeding of the complete sample stream into online GC’s. This enables us to achieve complete speciation and ensures the most accurate determination of the mass balance. Our on-line GC solutions utilize a multi-dimensional approach to analyze different component classes of the sample. It eliminates cold spots and enables shorter cycle times, facilitating fast feedback crucial for the control loop. By utilizing these features, we are able to provide efficient and timely results. 

With more that 100 Flowrence® systems worldwide, we developed on-line GC analytics for Hydrocracking, Hydrotreating, Fischer-Tropsch, Isomerization, Hydro isomerization, Methanol to Olefins, Reversed Water Gas Shift, CO2 to Methanol, CO2 to Hydrocarbons, Methanol to DME, Ammonia synthesis and cracking, and more. 

Ammonia chemistry involves components which are hard to analyze using either GC or MS. On-line high-resolution FT-IR makes use of the very narrow absorption bands as present in the gas phase. A model fed by a span of dilutions for all components calculates the sample composition. Cycle times are around 1.5 min. depending on composition and dilution. 

Custom-made units play a key role in advancing new sustainable chemistries, particularly those involving adsorption or other rapid processes. Our custom-made units are equipped with advanced technology, including on-line mass spectrometry, fast gas chromatography, and on-line FT-IR which enable the fast response required to monitor breakthrough curves and provide high data density. Simpler sample matrices benefit from expedited analysis capabilities of online GC or MS. In some cases, online FT-IR can analyze target components that are not resolved by other techniques.  

Analytics for adsorption processes on BTEX streams require high data density. Optimization of chromatography and data acquisition results in fast online GC analysis with cycle times of less than 1 minute. Ethylbenzene, p- and m-xylene are well separated and quantified.  

Online MS is frequently applied to adsorption processes because of its speed and ability to distinguish between mass fragments of small molecules. Data density is by a cycle time of less than 12 sec. is high enough to study breakthrough curves of for example CO2 adsorption. 

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Single-Pellet-String-Reactors (SPSR)

No dead-zones, no bed packing & distribution effects. The catalyst packing is straightforward and does not require special procedures. A single string of catalyst particles is loaded in the reactors with an internal diameter (ID) that closely matches the particle average diameter. This applies to single catalyst systems, as well as stacked-bed systems. The use of a narrow reactor avoids any maldistribution of gas and liquid over the catalyst bed, thereby eliminating catalyst-bed channeling and incomplete wetting of the catalyst.

The most accurate and stable pressure regulator for 16-parallel reactors

The most accurate and stable pressure regulator for a multi-parallel reactors with just ±0.1bar RSD at reference conditions. The Reactor Pressure Controller (RPC) uses microfluidics technology to individually regulate the back-pressure of each reactor. By measuring the inlet pressure of each reactor, the RPC maintains a constant inlet pressure by regulating the backpressure. As a result, the distribution of the inlet flows over the 16 reactors is unaffected and a low reactor-to-reactor flow variability is achieved.

Reactor pressure control is not only important to ensure accurate pressure control, but also to help maintaining equal distribution of the inlet flow over the 16 reactors.

Automated liquid sampling system

Programmable, fully automated liquid product sampling robot for 24/7 hands-off operation. Robot equipped with a compact manifold aiming at depressurizing the effluent immediately after each reactor to atmospheric pressure. Reactor effluent is depressurized by a miniaturized (low volume) parallel dome regulator, allowing a stable control of gas or gas/liquid product streams. This eliminates the use of valves at high pressure (such as multi-position valves), which are prone to leakage.

Gas liquid separation is sone directly by collecting the liquid products in sample vials and directing the gas products to the online gas analyzer. This approach minimizes required flushing times in the downstream section of the reactor eliminating the need for high pressure gas-liquid separators, level sensors, and drain valves.

EasyLoad® reactor closing system

Unique reactor closing system, no connections required. With a rapid reactor replacement minimizing delays, improving uptime and reliability. Sealing of up to 16 reactors by simply closing the ‘top-box’ in a single action. No leak testing required!

Stable evaporation by liquid injection into reactor

The direct injection of liquid into the top of the reactor and the consecutive conditioning zone allows feeding of broad range of liquids and concentrations. Various types of liquids, both aqueous and oil phase are successfully evaporated and fed to the reactors.

Tube-in-tube reactor technology with effluent dilution

This unique tube-in-tube feature allows an easy and rapid exchange of the reactor tubes (within minutes!) with a single o-ring at the top of the reactor without the need for any connections. The use of an inert diluent gas (outside of reactor) to maintain the pressure stops undesirable reactions immediately after the catalyst bed while serving as a carrier gas to the GC, facilitating the analysis of high boiling point components, preventing dead volumes and back flow, and reducing the time required to transfer gas and liquid effluent products to the analytical instruments.

The tube-in-tube design enables the use of quartz reactors at high pressure applications.

Compact TinyPressure module glass-chip holder with integrated pressure measurement

Holds the microfluidic glass-chips for gas distribution and measures inlet (and outlet) pressure of the 16 parallel reactors at ambient temperature, allowing online measurement of catalyst bed pressure drop.

No high-temperature pressure sensors required. Pressure range of 10 – 200 bar (high pressure) or 0.5 – 10 bar (low pressure).

The modular design enables easy calibration and quick exchange of the microfluidic glass-chip, without the need for time-consuming leak testing.

Microfluidics modular gas distribution

Unrivalled accuracy in gas distribution with patented glass-chips for 4 and 16 reactors, tested with a guaranteed flow distribution of 0.5% RSD channel-to-channel variability. Quick exchange for different operating conditions, offering the unique flexibility to cover a wide range of applications using the same reactor system.

Auto-calibrating liquid feed distribution, measurement, and control

The most accurate liquid distribution for high throughput systems with real-time liquid flow measurement and control for 16-parallel reactors. Auto-calibrating function enabled by a single flow sensor guarantees that all 16 reactors are continuously operated at the desired LHSV, all the time. Innovative design based on our microfluidic glass-chips with integrated temperature-control. The system continuously regulates the liquid distribution to all 16 reactors, and together with our Reactor Pressure Control technology, eliminates the impacts of pressure variations in the flow distribution.

Proven technology with difficult feedstocks with high viscosity, such as VGO, HVGO and DAO: no blockage and or breakage observed. Different glass-chips available for different viscosities.

Liquid distribution errors below 0.2% RSD, making it the most accurate parallel liquid flow distribution device on the market.

Option to selectively isolate the liquid flow to any of the 16-parallel reactors.


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