How to get even more value out of your Flowrence?

In Avantium we are focused on continuously improving our Flowrence platform to maximize precision and uptime. To this aim we have developed unique, Avantium designed modules, tailored for the needs in high-throughput experimentation. We now also want to make these improvements available for existing Flowrence users.

In this article the following upgrade possibilities are presented:

  • Microfluidic distributor chips
  • Active Liquid Distribution
  • Reactor Pressure Control

The added value you will receive as a user is clearly highlighted for each upgrade option. For more information, please contact us to discuss your particular situation and possibilities.

Increasing your data quality and uptime with our microfluidic distributor chips

Gas and liquid feeds, can be efficiently distributed using our microfluidic distributor chips. This technology provides a very narrow distribution of feeds to the parallel reactors. Various types of chips are available to be able to cover a wide range of flow rates and feed properties. Each chip is manufactured according to strict specifications to guarantee the quality of the distribution. The replacement of the chips can be done in minutes, offering much more operational flexibility while still using the same reactor system. Compared to historical hand-cut-capillary based distribution systems, this new technology reduces maintenance efforts and ultimately increases your uptime significantly, while providing more consistent data.


Reach unparalleled precision with our Active Liquid Distribution system (ALD)

We have specifically developed the Active Liquid Distribution system (ALD) to serve the most demanding applications with the highest possible precision. The ALD works by individually controlling the liquid flow to each reactor such that it converges to the average over all reactors, thereby ensuring perfectly equal liquid feed distribution. The unique design is based on Avantium’s proven proprietary microfluidic glass chips therefore providing a highly accurate flow control.  An added advantage is its auto-calibrating function, avoiding the need for time consuming tuning by the operator.

High accuracy for low pressure applications with our Reactor Pressure Control (RPC)

Our Reactor Pressure Controller (RPC) is based on Avantium’s proprietary’s microfluidic technology and will help you make maximum use of your unit by reducing the likelihood of pressure-related outliers.

It  will also allow you to mitigate differences in pressure drop over the catalyst bed, particularly when restrictions form with time on stream. The extremely narrow inlet pressure control obtained at all time will greatly improve the flow distribution to the parallel reactors.

The module has been designed to work hand in hand with our TinyPressure modules combining  microfluidic chip technology and individual reactor pressure measurement. The reactor inlet or outlet pressure is thus continuously monitored with the RPC adjusting automatically the back-pressure of each reactor providing a very precise pressure control for each reactor. This is particularly critical for low pressure applications, where high relative errors in pressure can have visible effects on catalyst activity and comparison.

It can be easily installed on existing parallel pressure regulators (PPR) and connected to already present TinyPressure modules. As an autonomous system which doesn’t require daily supervision this greatly enhances your precision while not compromising on uptime.

Single-Pellet-String-Reactors (SPSR)

No dead-zones, no bed packing & distribution effects. The catalyst packing is straightforward and does not require special procedures. A single string of catalyst particles is loaded in the reactors with an internal diameter (ID) that closely matches the particle average diameter. This applies to single catalyst systems, as well as stacked-bed systems. The use of a narrow reactor avoids any maldistribution of gas and liquid over the catalyst bed, thereby eliminating catalyst-bed channeling and incomplete wetting of the catalyst.

The most accurate and stable pressure regulator for 16-parallel reactors

The most accurate and stable pressure regulator for a multi-parallel reactors with just ±0.1bar RSD at reference conditions. The Reactor Pressure Controller (RPC) uses microfluidics technology to individually regulate the back-pressure of each reactor. By measuring the inlet pressure of each reactor, the RPC maintains a constant inlet pressure by regulating the backpressure. As a result, the distribution of the inlet flows over the 16 reactors is unaffected and a low reactor-to-reactor flow variability is achieved.

Reactor pressure control is not only important to ensure accurate pressure control, but also to help maintaining equal distribution of the inlet flow over the 16 reactors.

Automated liquid sampling system

Programmable, fully automated liquid product sampling robot for 24/7 hands-off operation. Robot equipped with a compact manifold aiming at depressurizing the effluent immediately after each reactor to atmospheric pressure. Reactor effluent is depressurized by a miniaturized (low volume) parallel dome regulator, allowing a stable control of gas or gas/liquid product streams. This eliminates the use of valves at high pressure (such as multi-position valves), which are prone to leakage.

Gas liquid separation is sone directly by collecting the liquid products in sample vials and directing the gas products to the online gas analyzer. This approach minimizes required flushing times in the downstream section of the reactor eliminating the need for high pressure gas-liquid separators, level sensors, and drain valves.

EasyLoad® reactor closing system

Unique reactor closing system, no connections required. With a rapid reactor replacement minimizing delays, improving uptime and reliability. Sealing of up to 16 reactors by simply closing the ‘top-box’ in a single action. No leak testing required!

Stable evaporation by liquid injection into reactor

The direct injection of liquid into the top of the reactor and the consecutive conditioning zone allows feeding of broad range of liquids and concentrations. Various types of liquids, both aqueous and oil phase are successfully evaporated and fed to the reactors.

Tube-in-tube reactor technology with effluent dilution

This unique tube-in-tube feature allows an easy and rapid exchange of the reactor tubes (within minutes!) with a single o-ring at the top of the reactor without the need for any connections. The use of an inert diluent gas (outside of reactor) to maintain the pressure stops undesirable reactions immediately after the catalyst bed while serving as a carrier gas to the GC, facilitating the analysis of high boiling point components, preventing dead volumes and back flow, and reducing the time required to transfer gas and liquid effluent products to the analytical instruments.

The tube-in-tube design enables the use of quartz reactors at high pressure applications.

Compact TinyPressure module glass-chip holder with integrated pressure measurement

Holds the microfluidic glass-chips for gas distribution and measures inlet (and outlet) pressure of the 16 parallel reactors at ambient temperature, allowing online measurement of catalyst bed pressure drop.

No high-temperature pressure sensors required. Pressure range of 10 – 200 bar (high pressure) or 0.5 – 10 bar (low pressure).

The modular design enables easy calibration and quick exchange of the microfluidic glass-chip, without the need for time-consuming leak testing.

Microfluidics modular gas distribution

Unrivalled accuracy in gas distribution with patented glass-chips for 4 and 16 reactors, tested with a guaranteed flow distribution of 0.5% RSD channel-to-channel variability. Quick exchange for different operating conditions, offering the unique flexibility to cover a wide range of applications using the same reactor system.

Auto-calibrating liquid feed distribution, measurement, and control

The most accurate liquid distribution for high throughput systems with real-time liquid flow measurement and control for 16-parallel reactors. Auto-calibrating function enabled by a single flow sensor guarantees that all 16 reactors are continuously operated at the desired LHSV, all the time. Innovative design based on our microfluidic glass-chips with integrated temperature-control. The system continuously regulates the liquid distribution to all 16 reactors, and together with our Reactor Pressure Control technology, eliminates the impacts of pressure variations in the flow distribution.

Proven technology with difficult feedstocks with high viscosity, such as VGO, HVGO and DAO: no blockage and or breakage observed. Different glass-chips available for different viscosities.

Liquid distribution errors below 0.2% RSD, making it the most accurate parallel liquid flow distribution device on the market.

Option to selectively isolate the liquid flow to any of the 16-parallel reactors.


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